| (B) |   1. | 
一位23歲男性過去無特殊不適,在當兵前體檢發現輕微貧血及黃疸,Hb 11.1 gm/dL, WBC 5990/uL,platelet 172000/uL,bilirubin全量4.1 mg/dL,直接型0.61 mg/dL,周邊血液抹片如圖所示。此位病人最可能的診斷為何?
 | 
| A. | Thalassemia | 
| B. | Hereditary spherocytosis | 
| C. | G6PD deficiency | 
| D. | Chronic hepatitis | 
| E. | Gilbert's disease | 
|   | 
| (D) |   2. | 
一位病人因為拔牙流血不止來到急診處,血液抹片如圖所示,這位病人最可能得了何種病?
 | 
| A. | Lymphoma | 
| B. | Chronic myeloid leukemia | 
| C. | Acute lymphoblastic leukemia | 
| D. | Acute promyelocytic leukemia | 
| E. | Acute monocytic leukemia | 
|   | 
| (A) |   3. | 
一位50歲女性被診斷有portal vein thrombosis。周邊血液檢查發現有JAK2基因突變,此病人最可能有下列何種疾病?
 | 
| A. | Myeloproliferative neoplasm | 
| B. | Paroxysmal nocturnal hemoglobinuria | 
| C. | Protein S deficiency | 
| D. | Protein C deficiency | 
| E. | Antithrombin III deficiency | 
|   | 
| (E) |   4. | 
一位病人的周邊血出現芽細胞,骨髓檢查發現芽細胞為35%,myeloperoxidase為陰性,其細胞表面抗原表現如下CD2(-)CD3(-)CD13(-)CD19(-)CD20(-)CD33(+)CD41(+)CD61(+)。此病人最可能的診斷為何?
 | 
| A. | Early preB acute lymphoblastic leukemia | 
| B. | T-acute lymphoblastic leukemia | 
| C. | Acute erythroleukemia | 
| D. | Acute monocytic leukemia | 
| E. | Acute megakaryoblastic leukemia | 
|   | 
| (C) |   5. | 
Bortezomib目前已是多發性骨髓瘤的第一線用藥,其作用機轉為何?
 | 
| A. | Tyrosine kinase inhibitor | 
| B. | Immunomodulation | 
| C. | Proteosome inhibitor | 
| D. | Anti-angiogenesis | 
| E. | Anti-IL6 | 
|   | 
| (B) |   6. | 
下列有關transfusion related acute lung injury (TRALI)的敘述,何者是錯誤的?
 | 
| A. | 一般在輸入帶有血漿的血液成分後發生 | 
| B. | 多在輸血後6至12小時中發生 | 
| C. | 病人的症狀為突發的呼吸急促並有肺部浸潤的現象 | 
| D. | 可能的機轉為輸入的血液成分中有對抗受血者白血球抗原的抗體 | 
| E. | 由於類固醇的治療效果並不確定,一般不建議作為例行治療之用 | 
|   | 
| (A) |   7. | 
一位25歲女性開刀後出血不止,抽血檢查發現 Hb 10.5gm/dL,WBC 4350/uL,分類正常,血小板 247000/uL,PT 10.1" (正常8"~12.2"),INR 0.96,aPTT 46" (正常26.9"~36.3")。為診斷病人出血傾向的原因,下列何種檢查最不需要?
 | 
| A. | Lupus anticoagulant | 
| B. | Factor VIII | 
| C. | vWF | 
| D. | Platelet function test | 
| E. | Ristocetin cofactor activity | 
|   | 
| (B) |   8. | 
一位29歲女性無特殊不適,三年前公司例行體檢的血液相顯示Hb 11.5 gm/dL,MCV 84fL,WBC 4750/uL,血小板 325000/uL。今年的體檢顯示Hb 9.8 gm/dL,MCV 70fL,WBC 3350/uL,分類正常,血小板416000/uL。理學檢查除結膜稍微蒼白外,無其他異常。此位病人最可能的診斷為何?
 | 
| A. | Thalassemia | 
| B. | Iron deficiency | 
| C. | Anemia of chronic disorder | 
| D. | Essential thrombocythemia | 
| E. | Myelodysplastic syndrome | 
|   | 
| (C) |   9. | 
下列有關paroxysmal nocturnal hemoglobinuria(PNH) 病人的敘述何者是正確的?(應選出所有正確答案)
(1)周邊血常呈現全血球減少
(2)血球上缺乏CD53及CD58
(3)易發生靜脈栓塞
(4)Eculizumab可改善病人的症狀
 | 
| A. | (1)+(4) | 
| B. | (2)+(3) | 
| C. | (1)+(3)+(4) | 
| D. | (2)+(3)+(4) | 
| E. | (1)+(2)+(3)+(4) | 
|   | 
| (E) |  10. | 
下列微生物及其相關之淋巴瘤的配對,何者是正確的?
(應選出所有正確答案)
(1)Helicobacter pylori, gastric MALT lymphoma
(2)EB virus, NK/T cell lymphoma
(3)HTLV-I, adult T cell lymphoma/leukemia
(4)HCV, lymphoplasmacytoid lymphoma
 | 
| A. | (1) | 
| B. | (2)+(3) | 
| C. | (1)+(3) | 
| D. | (1)+(2)+(3) | 
| E. | (1)+(2)+(3)+(4) | 
|   |