| (C) | 1. |
下列有關疾病與免疫功能異常的配對中，何者最為正確？
|
| A. | Mycobacterial infection - antibody deficiency |
| B. | Recurrent Streptococcus pneumoniae infection- cellular deficiency |
| C. | Recurrent skin pyogenic infections - phagocytic defect |
| D. | Recurrent Neisseria infection - antibody deficiency |
| E. | Inflammatory diseases - complement deficiency |
| |
| (B) | 2. |
下列有關生物製劑與疾病治療的配對中，何者最為正確？
|
| A. | Soluble CTLA-4 protein - T cell lymphoma |
| B. | Anti-TNF-α monoclonal antibody - rheumatoid arthritis |
| C. | IVIG - multiple myeloma |
| D. | Anti - CD20 monoclonal antibody - acute B cell leukemia |
| E. | Anti-IL-6 receptor monoclonal antibody - SLE |
| |
| (D) | 3. |
下列有關過敏性鼻炎治療的描述中，何者最為正確？
|
| A. | Immunotherapy對任何屬性的過敏性鼻炎都是最好的治療選擇 |
| B. | 單株抗IgE抗體對allergen-specific IgE升高的鼻炎患者最有效 |
| C. | 口服α-adrenergic agonist是首選治本的藥物 |
| D. | Intra-nasal high-potency glucocorticoids的使用對過敏症狀最有效 |
| E. | 輕度、間歇性的過敏性鼻炎發作時可以短期使用高劑量的口服類固醇治療 |
| |
| (B) | 4. |
一位57歲女性，近二年來發現冬季天冷時，右手第三及第四指的指甲會變白變紫。最近一年來兩側手背的皮膚變厚變硬。喝水時偶而會嗆到及有乾咳發生。到診所抽血發現ANA 1:5120 speckled + 1:320 centromere pattern，C3 109 mg/dL，C4 21.4 mg/dL，anti-dsDNA 42.5 IU/mL (normal < 120 IU/mL)、anti-SSA 25.4 U/mL (< 12.0 U/mL)，anti-SSB 8.6 U/mL (< 12.0 U/mL)。請問最有可能的診斷為：
|
| A. | SLE |
| B. | Systemic sclerosis |
| C. | Sjogren's syndrome |
| D. | Psoriasis |
| E. | Cutaneous vasculitis |
| |
| (A) | 5. |
一位46歲的男性，過去有重複性的左側腮腺腫大。最近半個月來有明顯的消化不良及食慾不振。另外，也有眼乾及口乾發生。抽血檢查發現ANA: 1:80 speckled，AST 38 U/L，ALT 62 U/L，anti-SSA 8 U/mL (<12 U/mL)，anti-SSB 11 U/mL (<12 U/mL)，amylase 185 U/L。腹部超音波發現胰臟頭部腫大且有纖維化。請問下列的何種檢查對疾病診斷最有幫助？
|
| A. | Serum IgG4 |
| B. | Serum electrophoresis |
| C. | Anti-aquaporin 4 antibodies |
| D. | Minor salivary gland biopsy |
| E. | Sialoscintigraphy |
| |
| (C) | 6. |
一位21歲的男性，早晨起來有下背痛達5個月之久。起床以後稍事運動20分之後，下背的僵硬及痠痛很快就會緩解。經多家醫院檢查包括，ESR 2 mm/1h、CRP<0.3 mg/dL、骨盆X-光照相無明顯的sacroiliitis。請問下列的何種檢查對於診斷axial spondyloarthropathy最有幫助？
|
| A. | Soft tissue sonography |
| B. | Inflammatory bone scan |
| C. | Dynamic MRI test |
| D. | HLA-B27 genotyping |
| E. | Lumbar spine mobility test |
| |
| (D) | 7. |
一位69歲的痛風患者，過去有尿路結石的病史。因經常使用NSAIDS以致腎功能受損。血液檢查發現BUN 34 mg/dL，creatinine 2.3 mg/dL，uric acid 9.1 mg/dL。另外檢測HLA發現為HLA-B*5801帶原者。請問使用下列何種藥物來降尿酸最為適當？
|
| A. | Allopurinol |
| B. | Probenecid |
| C. | Benzbromarone |
| D. | Febuxostat |
| E. | Colchicine |
| |
| (E) | 8. |
在SLE患者的血清中含有各式各樣的抗體。請問下列何者才是最正確的組合抗體？ (1) ACPA (2) ANCA (3) anti-SSA/anti-SSB (4) anti-histone (5) anti-Sm/ anti-RNP (6) anti-lymphocyte (7) anti-mitochondria (8) anti-LKM (9) anti-centromere
|
| A. | (1)+(3)+(9) |
| B. | (2)+(6)+(8) |
| C. | (3)+(4)+(7) |
| D. | (1)+(5)+(8) |
| E. | (4)+(5)+(6) |
| |
| (B) | 9. |
與rheumatoid arthritis相關的因子很多，請問下列哪些cytokines/ chemokines 與rheumatoid pathogenesis最有相關？
(1) IL-2 (2) IL-1 (3) IL-6 (4) TGF-β (5) TNF-α (6) IL-4 (7) G-CSF (8) IFN-γ (9) IL-10
|
| A. | (1)+(2)+(4) |
| B. | (3)+(5)+(8) |
| C. | (4)+(6)+(7) |
| D. | (2)+(8)+(9) |
| E. | (1)+(5)+(7) |
| |
| (C) | 10. |
下列的哪種血管炎有可能會產生anti-neutrophil cytoplasmic antibodies (ANCAs) ? (1) giant cell arteritis (2) polyarteritis nodosa (3) idiopathic cutaneous vasculitis (4) granulomatosis with polyangiitis (5) hepatitis C-associated cryoglobulinemic vasculitis (6) microscopic polyangiitis (7) Kawasaki disease (8) Churg-Strauss syndrome (9) Takayasu's arteritis
|
| A. | (1)+(2)+(4) |
| B. | (2)+(5)+(7) |
| C. | (4)+(6)+(8) |
| D. | (3+(5)+(9) |
| E. | (5)+(6)+(7) |
| |